The Multiple Faces of Systemic Lupus Erythematosus
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چکیده
SYSTEMIC LUPUS ERYTHEMATOSUS Systemic lupus erythematosus (SLE), the prototype of systemic autoimmune disorders, has been considered for many years a classic model of immune complex mediated disease. However, earlier data demonstrate that multilevel dysfunction of cellular and humoral immunity underlie the pathophysiology of the disorder. 2 The expression and clinical course of SLE vary enormously from very mild, with arthralgias and skin rashes, to life threatening, when the renal and central nervous system function are severely compromised; from complete quiescence to full blown expression of the disease. Coexistence or even evolution into other types of autoimmune disorders, such as Sjögren’s syndrome and mixed connective tissue disease can also occur. Finally, subsets of SLE were early recognised: distinct clinical entities such as antiphospholipid syndrome (APS) or subacute lupus erythematosus are considered to be part of the “SLE” clinical spectrum.
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